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(Artigo 9 publicado v.28 n.2) Valores de referência de alguns parâmetros fisiológicos de ratos do Biotério Central da Universidade Estadual de Maringá, Estado do Paraná

2006; UNIVERSIDADE ESTADUAL DE MARINGÁ; Volume: 28; Issue: 2 Linguagem: Inglês

10.4025/actascihealthsci.v28i2.1099

1807-8648

Ciomar Aparecida Bersani Amado, Jailson Araújo Dantas, Célia Regina Ambiel, Roberto Kenji Nakamura Cuman, Silmara Baroni,

Animal testing and alternatives

The present work was carried out to establish reference values for some physiological parameters (biochemical, hematological and urinary) in rats proceeding from the Central Biotery at the State University of Maringá, State of Paraná. Normal male Wistar rats weighing 200-220 g were used. The hematological profile (total leukocytes, mononuclear and polymorphonuclear cells count), the clinic chemistry (aspartate aminotransferase, alanine aminotransferase, glucose, creatinine, alkaline phosphatase, acid phosphatase, urea, cholesterol, HDL-c, triglycerides, glucose tolerance) and urinary parameters (glucose and creatinine) were determined. Each laboratory should establish a database of reference values for their animals, according to diet, strain, sex and age for each species used. Thus, in this work, a database is provided regarding reference values of some physiological parameters in rats for use in experimental investigations