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Immune complexes in serum and cerebrospinal fluid of multiple sclerosis patients and patients with other neurological diseases

2009; Wiley; Volume: 66; Issue: 1 Linguagem: Inglês

10.1111/j.1600-0404.1982.tb03124.x

1600-0404

A. Salmi, Barry Ziola, Mauri Reunanen, Ilkka Julkunen, O Wäger,

Toxin Mechanisms and Immunotoxins

Acta Neurologica ScandinavicaVolume 66, Issue 1 p. 1-15 Immune complexes in serum and cerebrospinal fluid of multiple sclerosis patients and patients with other neurological diseases RESULTS OF 4 DIFFERENT IMMUNE COMPLEX ASSAYS Dr. A. Salmi M.D., Corresponding Author Dr. A. Salmi M.D. The Neurovirology Study Group, Department of Virology, University of Turku, Turku, FinlandThe Neurovirology Study Group Department of Virology University of Turku Kiinamyllynkatu 10 SF-20520 Turku 52 FinlandSearch for more papers by this authorB. Ziola, B. Ziola Department of Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaSearch for more papers by this authorM. Reunanen, M. Reunanen Department of Neurology, University of Oulu, FinlandSearch for more papers by this authorI. Julkunen, I. Julkunen Department of Virology, University of HelsinkiSearch for more papers by this authorO. Wager, O. Wager Municipal Bacteriological Laboratory, Aurora Hospital, Helsinki, FinlandSearch for more papers by this author Dr. A. Salmi M.D., Corresponding Author Dr. A. Salmi M.D. The Neurovirology Study Group, Department of Virology, University of Turku, Turku, FinlandThe Neurovirology Study Group Department of Virology University of Turku Kiinamyllynkatu 10 SF-20520 Turku 52 FinlandSearch for more papers by this authorB. Ziola, B. Ziola Department of Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaSearch for more papers by this authorM. Reunanen, M. Reunanen Department of Neurology, University of Oulu, FinlandSearch for more papers by this authorI. Julkunen, I. Julkunen Department of Virology, University of HelsinkiSearch for more papers by this authorO. Wager, O. Wager Municipal Bacteriological Laboratory, Aurora Hospital, Helsinki, FinlandSearch for more papers by this author First published: July 1982 https://doi.org/10.1111/j.1600-0404.1982.tb03124.xCitations: 22AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Paired serum and cerebrospinal fluid (CSF) specimens from 30 multiple sclerosis (MS) patients and 30 patients with other neurological diseases (ONDs) were analyzed for the presence of immune complexes (ICs). With each of the 4 tests used, ICs were found more frequently in sera from both MS and OND patients than in sera from healthy blood donors. IC-positivity for MS and OND patient CSF varied from 10-33 % and from 10-17 % in different tests. The number of IC-positive sera or CSF in MS patients did not differ significantly from those in OND patients. For both MS and OND patients, the positivity pattern for serum and CSF specimens in each IC test was essentially unique. Furthermore, because several CSF IC-positive and serum IC-negative paired specimens were found, intrathecal IC formation may be independent of IC formation in peripheral blood. The presence of ICs in serum or CSF did not correlate with the clinical status of or laboratory data on the MS patients, nor was a correlation found with the diagnosis of the OND patients. In total, these results suggest that the presence or absence of ICs in MS or OND patients may simply reflect changes in the immunological regulation of individual patients. Citing Literature Volume66, Issue1July 1982Pages 1-15 RelatedInformation