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Base composition of nonsense codons in Escherichia coli

1967; Elsevier BV; Volume: 23; Issue: 3 Linguagem: Inglês

10.1016/s0022-2836(67)80113-x

1089-8638

Martin Weigert, Erich Lanka, Alan Garen,

Fungal and yeast genetics research

Earlier oxperiments showed that the triplet UAG was the nonsense condon produced by the N1 class of alkaline phosphatase nonsense mutations. In the present experiments UAA has been identified as a second nonsense codon produced by the N2 class of alkaline phosphatase nonsense mutations. The composition of each nonsense codon was established on the basis of amino acid substitutions occurring in alkaline phosphatase as a result of mutationally induced alterations of the nonsense codons. The substitution data further indicate that UGA is not a codon for tryptophan in Escherichia coli and might act as a third nonsense codon.