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POxylated Polyurea Dendrimers: Smart Core-Shell Vectors with IC 50 Lowering Capacity

2015; Wiley; Volume: 15; Issue: 8 Linguagem: Inglês

10.1002/mabi.201500131

1616-5195

Rita B. Restani, João Conde, Rita F. Pires, Pedro Martins, Alexandra R. Fernandes, Pedro V. Baptista, Vasco D. B. Bonifácio, Ana Aguiar‐Ricardo,

Polymer Surface Interaction Studies

The design and preparation of highly efficient drug delivery platforms using green methodologies is at the forefront of nanotherapeutics research. POxylated polyurea dendrimers are efficiently synthesized using a supercritical-assisted polymerization in carbon dioxide. These fluorescent, pH-responsive and water-soluble core-shell smart nanocarriers show low toxicity in terms of cell viability and absence of glutathione depletion, two of the major side effect limitations of current vectors. The materials are also found to act as good transfection agents, through a mechanism involving an endosomal pathway, being able to reduce 100-fold the IC50 of paclitaxel.