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A quantitative study of the pregnancy zone protein in the sera of pregnant and puerperal women

1974; Elsevier BV; Volume: 119; Issue: 6 Linguagem: Inglês

10.1016/0002-9378(74)90092-1

1097-6868

Bo von Schoultz,

T-cell and Retrovirus Studies

The serum concentration of the pregnancy zone protein (PZ) was measured by means of single radial immunodiffusion in 72 primigravidas who were followed during pregnancy and after delivery. The concentration of this α2-globulin in most women was found to increase rapidly at the end of the first trimester. In the third trimester the average concentration was more stable around 100 mg. per 100 ml. After delivery there was a rapid decrease, and 6 weeks post partum no women had concentrations exceeding 10 mg. per 100 ml. The possibility that PZ is involved in immunoregulatory mechanisms during pregnancy is discussed.