BTG1, a member of a new family of antiproliferative genes.
1992; Springer Nature; Volume: 11; Issue: 4 Linguagem: Inglês
10.1002/j.1460-2075.1992.tb05213.x
ISSN1460-2075
AutoresJean-Pierre Rouault, Ruth Rimokh, C. Tessa, Giovanne Dos Santos Paranhos, Martine Ffrench, Laurent Duret, M. Garoccio, D Germain, Jacques Samarut, J.P. Magaud,
Tópico(s)Cancer-related gene regulation
ResumoResearch Article1 April 1992free access BTG1, a member of a new family of antiproliferative genes. J.P. Rouault J.P. Rouault Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author R. Rimokh R. Rimokh Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author C. Tessa C. Tessa Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author G. Paranhos G. Paranhos Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author M. Ffrench M. Ffrench Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author L. Duret L. Duret Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author M. Garoccio M. Garoccio Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author D. Germain D. Germain Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author J. Samarut J. Samarut Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author J.P. Magaud J.P. Magaud Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author J.P. Rouault J.P. Rouault Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author R. Rimokh R. Rimokh Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author C. Tessa C. Tessa Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author G. Paranhos G. Paranhos Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author M. Ffrench M. Ffrench Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author L. Duret L. Duret Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author M. Garoccio M. Garoccio Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author D. Germain D. Germain Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author J. Samarut J. Samarut Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author J.P. Magaud J.P. Magaud Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. Search for more papers by this author Author Information J.P. Rouault1, R. Rimokh1, C. Tessa1, G. Paranhos1, M. Ffrench1, L. Duret1, M. Garoccio1, D. Germain1, J. Samarut1 and J.P. Magaud1 1Equipe de Cytologie Analytique et de Cytogénétique Moléculaire Hôpital Edouard Herriot, Lyon, France. The EMBO Journal (1992)11:1663-1670https://doi.org/10.1002/j.1460-2075.1992.tb05213.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. We report here the cloning and sequencing of the human BTG1 cDNA and establish the genomic organization of this gene. The full-length cDNA isolated from a lymphoblastoid cell line contains an open reading frame of 171 amino acids. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and is down-regulated when cells progress throughout G1. Furthermore, transfection experiments of NIH3T3 cells indicate that BTG1 negatively regulates cell proliferation. The BTG1 open reading frame is 60% homologous to PC3, an immediate early gene induced by nerve growth factor in rat PC12 cells. Sequence and Northern blot analyses indicate that BTG1 and PC3 are not cognate genes. We then postulate that these two genes are the first members of a new family of antiproliferative genes. Previous ArticleNext Article Volume 11Issue 41 April 1992In this issue RelatedDetailsLoading ...
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