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Analysis of chemical warfare agents

2005; Elsevier BV; Volume: 1098; Issue: 1-2 Linguagem: Inglês

10.1016/j.chroma.2005.08.070

1873-3778

Bob Muir, David B. Cooper, Wendy A. Carrick, Christopher M. Timperley, Ben Slater, Suzanne Quick,

Mass Spectrometry Techniques and Applications

The reactivity of phosgene and perfluoroisobutylene (PFIB) towards 1,2-bis-nucleophiles was exploited to allow determination of these gases in air samples. 2-Aminothiophenol (ATP), 3,4-dimercaptotoluene (DMT) and 2-hydroxymethylpiperidine (HMP) were evaluated as bis-nucleophiles capable of forming thermally-stable derivatives with phosgene and PFIB when loaded with triethylamine onto Tenax TA. Experimental design was used to optimise thermal desorption conditions. Detection limits in the low ng m−3 range were observed for the five derivatives investigated. This work represents the most sensitive analytical method for trace level quantitation of phosgene and PFIB published to date.