Trehalose 6-Phosphate Synthetase (Uridine Diphosphate Glucose:D-Glucose 6-Phosphate 1-Glucosyltransferase) and Its Regulation during Slime Mold Development
1968; Elsevier BV; Volume: 243; Issue: 19 Linguagem: Inglês
10.1016/s0021-9258(18)91994-0
ISSN1083-351X
AutoresRobert M. Roth, Maurice Sussman,
Tópico(s)Fungal and yeast genetics research
ResumoAbstract During morphogenesis in the cellular slime mold Dictyostelium discoideum, trehalose-6-P synthetase activity, undetectable in the vegetative cell, appears, accumulates to a peak, and then disappears. Both the accumulation and disappearance are sensitive to coincident inhibition of protein synthesis by cycloheximide and prior inhibition of RNA synthesis by actinomycin D. The normal pattern of changes in enzyme activity observed in the wild type is modified in specific ways in mutants displaying morphogenetic aberrations.
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