Produção Nacional
Revisado por pares
C ymbopogon martinii essential oil and geraniol at noncytotoxic concentrations exerted immunomodulatory/anti-inflammatory effects in human monocytes
2014; Oxford University Press; Volume: 66; Issue: 10 Linguagem: Inglês
10.1111/jphp.12278
ISSN2042-7158
AutoresBruna Fernanda Murbach Teles Andrade, Bruno José Conti, Karina Basso Santiago, Ary Fernandes Júnior, José Maurício Sforcin,
Tópico(s)Herbal Medicine Research Studies
ResumoIn traditional medicine, plants have formed the basis of sophisticated systems that have been in existence for thousands of years and still provide mankind with new remedies. Cymbopogon martinii, known as palmarosa, has been used in aromatherapy as a skin tonic due to its antimicrobial properties. It has also used in Ayurvedic medicine for skin problems and to relieve nerve pain. The immunomodulatory action of C. martinii essential oil (EO) and geraniol was evaluated regarding the production of pro- and anti-inflammatory cytokines (tumour necrosis factor (TNF)-α and IL-10, respectively) by human monocytes in vitro.Monocyte cultures were incubated with EO or geraniol. After 18 h, cytotoxicity assays were performed using 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide method, and cytokine production was determined by ELISA.The variables showed no cytotoxic effects on monocytes. TNF-α production was not affected by C. martinii and geraniol, and only the concentration of 5 μg/ml of C. martinii stimulated its production. On the other hand, all concentrations of C. martinii and geraniol increased IL-10 production by human monocytes.Data showed that noncytotoxic concentrations of EO and geraniol exerted an anti-inflammatory action by increasing IL-10 production; moreover, geraniol seemed to be probably responsible for EO immunomodulatory activity in our assay condition.
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