Engagement of NKG2D by Cognate Ligand or Antibody Alone Is Insufficient to Mediate Costimulation of Human and Mouse CD8+ T Cells
2005; American Association of Immunologists; Volume: 174; Issue: 4 Linguagem: Inglês
10.4049/jimmunol.174.4.1922
ISSN1550-6606
AutoresLauren I. R. Ehrlich, Kouetsu Ogasawara, Jessica A. Hamerman, Rayna Takaki, Alessandra Zingoni, James P. Allison, Lewis L. Lanier,
Tópico(s)CAR-T cell therapy research
ResumoAbstract CD8+ T cells require a signal through a costimulatory receptor in addition to TCR engagement to become activated. The role of CD28 in costimulating T cell activation is well established. NKG2D, a receptor found on NK cells, CD8+ αβ-TCR+ T cells, and γδ-TCR+ T cells, has also been implicated in T cell costimulation. In this study we have evaluated the role of NKG2D in costimulating mouse and human naive and effector CD8+ T cells. Unexpectedly, in contrast to CD28, NKG2D engagement by ligand or mAb is not sufficient to costimulate naive or effector CD8+ T cell responses in conventional T cell populations. While NKG2D did not costimulate CD8+ T cells on its own, it was able to modify CD28-mediated costimulation of human CD8+ T cells under certain contitions. It is, therefore, likely that NKG2D acts as a costimulatory molecule only under restricted conditions or requires additional cofactors.
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