Muscarinic Receptor Subtype Pharmacology and Physiology
2005; Elsevier BV; Linguagem: Inglês
10.1016/s0079-6468(05)43004-0
ISSN1875-7863
Autores Tópico(s)Neuropeptides and Animal Physiology
ResumoThe role of muscarinic receptors is highly complex. The recent pharmacological evidence with novel compounds, together with data from transgenic mice, suggests that all five subtypes (muscarinic M1, M2, M3, M4, and M5 receptors) have a defined function in both peripheral and central nervous systems. Several novel agonists and antagonists have now been identified with authentic subtype specificity in vitro and in vivo, and additional opportunities for selective subtype modulation may arise from the development of selective allosteric regulators. Several clinical development programs are currently underway with selective M1 agonists, M1 allosteric regulators, or M2 antagonists for the treatment of Alzheimer's disease, as well as M3 antagonists for the treatment of overactive bladder or chronic obstructive pulmonary disease. These compounds may provide novel approaches for a variety of disorders, as well as advancing the current understanding of the metabotropic role of acetylcholine.
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