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A cluster of dispensable genes within the human cytomegalovirus genome short component: IRS1, US1 through US5, and the US6 family

1992; American Society for Microbiology; Volume: 66; Issue: 4 Linguagem: Inglês

10.1128/jvi.66.4.2541-2546.1992

1098-5514

Thomas R. Jones, V P Muzithras,

RNA regulation and disease

By insertional mutagenesis, human cytomegalovirus recombinants deleted of each of the US6 glycoprotein family genes were isolated. A recombinant lacking IRS1, US1 through US5, and most of the US6 family was also isolated. The growth kinetics of these mutants were similar to that of the wild type. A dispensable cluster of genes was identified.