Evidence for a Link Between Adipose Tissue Interleukin-6 Content and Serum C-Reactive Protein Concentrations in Obese Subjects
1999; Lippincott Williams & Wilkins; Volume: 99; Issue: 16 Linguagem: Inglês
10.1161/circ.99.16.2219/c
ISSN1524-4539
AutoresJean‐Philippe Bastard, Claude Jardel, Jacques Delattre, Bernard Hainque, Éric Bruckert, F Oberlin,
Tópico(s)Cardiovascular Disease and Adiposity
ResumoHomeCirculationVol. 99, No. 16Evidence for a Link Between Adipose Tissue Interleukin-6 Content and Serum C-Reactive Protein Concentrations in Obese Subjects Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBEvidence for a Link Between Adipose Tissue Interleukin-6 Content and Serum C-Reactive Protein Concentrations in Obese Subjects Jean-Philippe Bastard, Claude Jardel, Jacques Delattre and Bernard Hainque Eric Bruckert Flavien Oberlin Jean-Philippe BastardJean-Philippe Bastard Service de Biochimie B , Claude JardelClaude Jardel Service de Biochimie B , Jacques DelattreJacques Delattre Service de Biochimie B and Bernard HainqueBernard Hainque Service de Biochimie B Eric BruckertEric Bruckert Service d'Endocrinologie-Métabolisme Flavien OberlinFlavien Oberlin Service de Rhumatologie Groupe hospitalier Pitié-Salpêtrière AP-HP, Paris, France Originally published27 Apr 1999https://doi.org/10.1161/circ.99.16.2219/cCirculation. 1999;99:2219c–2222To the Editor:We read with interest the editorial by Tracy1 on inflammation in cardiovascular disease (CVD). Serum concentrations of C-reactive protein (CRP) were demonstrated to be related to increased risk of CVD, which underlines the potential inflammatory nature of human atherosclerosis.23 Interestingly, an unexpected association between CRP and body mass index (BMI) was found in several population studies234 without any explanation.1The production of CRP is regulated by cytokines, principally interleukin-6 (IL-6), and serum CRP levels reflect IL-6 activity in humans. It was demonstrated that IL-6 is released in vivo by subcutaneous adipose tissue and is thereby able to have systemic effects, particularly in obese subjects.5 Thus, we hypothesized that adipose tissue may play a role in the regulation of serum CRP concentrations via IL-6 production.To test this hypothesis, we measured CRP and IL-6 in both blood and adipose tissue from 13 fasting obese subjects (2 men, 11 women) aged 44±4 years (BMI, 39.1±1.3 kg/m2; percent fat mass, 44.3±2.4%). CRP concentrations were determined with a BNII nephelometer analyser (Behring). IL-6 concentrations were determined by ELISA (Quantikine, R&D Systems). Body composition analysis was carried out by dual x-ray absorptiometry (QDR 1000, Hologic).Serum CRP and IL-6 concentrations were 4.49±1.07 mg/L and 2.77±0.31 pg/mL, respectively. In adipose tissue, IL-6 concentrations were 12.81±1.28 pg/g fat, whereas CRP was undetectable. Serum CRP concentrations were significantly correlated with BMI (ρ=0.633, P<0.05), body fat mass (ρ=0.718, P<0.05), and percent fat mass (ρ=0.872, P<0.005) but not with lean body mass (ρ=−0.435, P=0.13). A strong correlation was found between serum CRP concentrations and adipose tissue IL-6 content when expressed as picogram per total fat mass (ρ=0.757, P<0.01) but not as picogram per gram of fat (ρ=0.446, P=0.12).These data are consistent with the role of human adipose tissue in the regulation of blood circulating CRP concentrations via IL-6 production in obesity. In addition, the higher IL-6 production from adipose tissue seems to be more related to the increase of total fat mass than an overexpression of IL-6 in adipose tissue. Because CRP was proposed as a predictive marker of CVD risk, whether slightly elevated concentrations of CRP are the consequence of adipose tissue secretion, an inflammatory process, or both remains to be established. References 1 Tracy RP. Inflammation in cardiovascular disease: cart, horse, or both? Circulation.1998; 97:2000–2002.CrossrefMedlineGoogle Scholar2 Mendall MA, Patel P, Ballam L, Strachan D, Northfield TC. C-reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. BMJ.1996; 312:1061–1065.CrossrefMedlineGoogle Scholar3 Haverkate F, Thompson SG, Pyke SD, Gallimore JR, Pepys MB. Production of C-reactive protein and risk of coronary events in stable and unstable angina: European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Lancet.1997; 349:462–466.CrossrefMedlineGoogle Scholar4 Tracy RP, Psaty BM, Macy E, Bovill EG, Cushman M, Cornell ES, Kuller LH. Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects. Arterioscler Thromb Vasc Biol.1997; 17:2167–2176.CrossrefMedlineGoogle Scholar5 Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab.1997; 82:4196–4200.MedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Park J (2022) Asthma Phenotype with Metabolic Dysfunction, Yonsei Medical Journal, 10.3349/ymj.2022.63.1.1, 63:1, (1), . 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