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Molecular Properties of Dihydropyridine-Sensitive Calcium Channels from Skeletal Muscle

1988; Springer Nature; Linguagem: Inglês

10.1007/978-3-642-73914-9_17

1431-116X

Michael Seagar, Masayuki Takahashi, W A Catterall,

Neuroscience and Neural Engineering

Voltage-sensitive calcium channels provide an essential link between transient changes in membrane potential and a variety of cellular responses. In neurons, calcium influx couples membrane depolarization to transmitter release at the synaptic terminal [1], whereas in the cell body it may activate calcium-dependent potassium channels and thus modulate repetitive firing patterns [2]. In cardiac and smooth muscle tissue, calcium channels mediate excitation-contraction coupling, although in skeletal muscle their physiological role is still a matter for debate [3,4].