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Growth and specification: fly Pax6 homologs eyegone and eyeless have distinct functions

2004; Wiley; Volume: 26; Issue: 6 Linguagem: Inglês

10.1002/bies.20055

1521-1878

Aloma B. Rodrigues, Kevin Moses,

Animal Genetics and Reproduction

Abstract Development requires not only the correct specification of organs and cell types in the right places (pattern), but also the control of their size and shape (growth). Many signaling pathways control both pattern and growth and how these two are distinguished has been something of a mystery. In the fly eye, a Pax6 homolog ( eyeless ) controls eye specification together with several other genes. Now Dominguez et al. 1 show that Notch signaling controls eye growth through a second Pax6 protein (Eyegone). In mice and humans the single Pax6 gene appears to encode both specification and growth controlling proteins through alternative mRNA splicing. BioEssays 26:600–603, 2004. © 2004 Wiley Periodicals, Inc.