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A comparison of the Aschheim-Zondek and the Friedman tests in normal and abnormal pregnancy

1934; Elsevier BV; Volume: 27; Issue: 2 Linguagem: Inglês

10.1016/s0002-9378(34)90967-4

1097-6868

Harold C. Mack, George H. Agnew,

Ectopic Pregnancy Diagnosis and Management

Abstract An analysis of the literature on hormone tests for pregnancy and our own experience with 546 Aschheim-Zondek and 566 Friedman tests demonstrates a high degree of accuracy for both methods, the latter being slightly more accurate as well as easier and quicker. In proved cases of normal pregnancy we obtained an accuracy of 97.3 per cent with the Aschheim-Zondek test and an accuracy of 97.8 per cent with the Friedman method. In patients definitely determined not to have been pregnant we obtained an accuracy of 98.5 per cent with both methods. In abnormal or interrupted pregnancy the result of the test should be interpreted with the clinical findings, a negative test signifies either a nonpregnant state or an interrupted pregnancy, a positive test strongly indicates living fetal elements, but due to a temporary persistence in elimination of the hormone, recent interruption or fetal death cannot be excluded. In cases of hydatidiform mole and malignant chorionepithelioma, the amount of hormone excreted is many times greater than that excreted during normal pregnancy. The persistence of positive tests after treatment of these neoplasms strongly suggests continued chorionic proliferation.