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Drug points: Hepatotoxicity associated with zolpidem treatment

1999; BMJ; Volume: 318; Issue: 7192 Linguagem: Inglês

10.1136/bmj.318.7192.1179

0959-8138

David Karsenti, P Blanc, Yannick Bacq, E H Metman,

Pharmacological Effects and Toxicity Studies

Zolpidem is a hypnotic drug of the imidazopyridine group. Another imidazopyridine, alpidem, has been withdrawn from the market because of its hepatotoxicity. 1 2 Hepatoxicity has been suspected in association with zolpidem, but it has not been clearly established because of concomitant drug treatment. 3 4 We report a case of acute hepatitis mimicking biliary lithiasis after treatment with zolpidem alone at a therapeutic dose, with reappearance of the hepatoxicity after the drug was reintroduced. A 53 year old woman was admitted in June 1997 for investigation of recurrent abdominal pain. She had no history of recent …