Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

The use of saliva as a practical and feasible alternative to urine in large-scale screening for congenital cytomegalovirus infection increasesinclusion and detection rates

2015; Brazilian Society of Tropical Medicine; Volume: 48; Issue: 2 Linguagem: Inglês

10.1590/0037-8682-0200-2014

1678-9849

Emanuelle Santos de Carvalho Cardoso, Bruna Laís Santos de Jesus, Luciano Gama da Silva Gomes, Sandra Mara Bispo Sousa, Sandra Rocha Gadelha, Lauro Juliano Marin,

Neonatal Health and Biochemistry

Although urine is considered the gold-standard material for the detection of congenital cytomegalovirus (CMV) infection, it can be difficult to obtain in newborns. The aim of this study was to compare the efficiency of detection of congenital CMV infection in saliva and urine samples.One thousand newborns were included in the study. Congenital cytomegalovirus deoxyribonucleic acid (DNA) was detected by polymerase chain reaction (PCR).Saliva samples were obtained from all the newborns, whereas urine collection was successful in only 333 cases. There was no statistically significant difference between the use of saliva alone or saliva and urine collected simultaneously for the detection of CMV infection.Saliva samples can be used in large-scale neonatal screening for CMV infection.