A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans
2000; Elsevier BV; Volume: 96; Issue: 5 Linguagem: Inglês
10.1182/blood.v96.5.1996
ISSN1528-0020
AutoresMichael H. Kohn, Hans‐Joachim Pelz,
Tópico(s)Receptor Mechanisms and Signaling
ResumoAbstract The locus underlying hereditary resistance to the anticoagulant warfarin (symbol in the rat, Rw) was placed in relation to 8 positionally mapped gene-anchored microsatellite loci whose positions were known in the genome maps of the rat, mouse, and human.Rw segregated with the markers Myl2 (zero recombinants) and Itgam, Il4r, andFgf2r (one recombinant each) during linkage analysis in a congenic warfarin- and bromadiolone-resistant laboratory strain of rats. Comparative ortholog mapping between rat, mouse, and human placedRw onto mouse chromosome 7 at about 60 to 63 cM and onto one of the human chromosomes 10q25.3-26, 12q23-q24.3, and 16p13.1-p11.
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