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BIBTEX RIS

Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat

1997; American Society for Microbiology; Volume: 71; Issue: 5 Linguagem: Inglês

10.1128/jvi.71.5.4098-4102.1997

ISSN

1098-5514

Autores

Y P Li,

Tópico(s)

Biochemical and Molecular Research

Resumo

Nucleolar shuttle protein B23 was found to bind to human immunodeficiency virus protein Tat, and this binding required the nucleolar localization motif of Tat. A fusion protein containing the B23 binding domain and beta-galactosidase caused mislocalization of Tat to the cytoplasm and inhibited the transactivation activity of Tat. These data suggest that B23 is a human factor necessary for the nucleolar localization of Tat.

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