Indomethacin Versus Radiation Therapy for Heterotopic Ossification After Hip Arthroplasty
2001; Slack Incorporated (United States); Volume: 24; Issue: 12 Linguagem: Inglês
10.3928/0147-7447-20011201-11
ISSN1938-2367
AutoresDarryl D. D’Lima, Eric Venn-Watson, Prabhakar Tripuraneni, Chris Cowell,
Tópico(s)Management of metastatic bone disease
ResumoABSTRACT This study compared the efficacy and cost of radiation therapy with indomethacin in the prophylaxis of heterotopic ossification following total hip replacement. Twenty-two patients received a radiation dose of 1 0 Gy in five fractions, 28 patients 8 Gy in one fraction, and 27 patients 25 mg oral indomethacin three times a day for either 7 or 21 days. Patients at higher risk for heterotopic ossification were more likely to receive radiation therapy than indomethacin. At a mean follow-up of 2 years, there were no differences in failure rates between the high-risk patients treated with radiation and the low-risk patients treated with indomethacin. Currently, the patient-billed cost of radiation is $1400 whereas the cost for indomethacin is approximately $100. indomethacin appears to be as effective as radiation therapy in patients at low to moderate risk for heterotopic ossification and offers significant cost savings.
Referência(s)