Configuration of latent varicella-zoster virus DNA
1995; American Society for Microbiology; Volume: 69; Issue: 12 Linguagem: Inglês
10.1128/jvi.69.12.8151-8154.1995
ISSN1098-5514
AutoresPenny Clarke, Thomas De Beer, Randall J. Cohrs, Don Gilden,
Tópico(s)Animal Virus Infections Studies
ResumoThe configuration of latent varicella-zoster virus (VZV) DNA was analyzed by PCR. Template DNA for both internal and terminal VZV primers was present in a 1:1 ratio in ganglionic DNA, compared with a 15:1 ratio in DNA extracted from VZV virions, indicating that the VZV genomic termini are adjacent in latently infected human ganglia.
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