Artigo Acesso aberto Revisado por pares

K Channels as Molecular Targets for the Treatment of Erectile Dysfunction

2002; Wiley; Volume: 23; Issue: 5 Linguagem: Inglês

10.1002/j.1939-4640.2002.tb02291.x

ISSN

2047-2927

Autores

George J. Christ,

Tópico(s)

Neuroendocrine regulation and behavior

Resumo

Journal of AndrologyVolume 23, Issue 5 p. S10-S19 Free Access K Channels as Molecular Targets for the Treatment of Erectile Dysfunction GEORGE J. CHRIST PhD, Corresponding Author GEORGE J. CHRIST PhD Professor Departments of Urology and Physiology & Biophysics, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New YorkDepartments of Urology and Physiology & Biophysics, Ben Marden Distinguished Scholar in Urology, Director, Institute for Smooth Muscle Biology, Room 744, Forchheimer Bldg, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461 (e-mail: [email protected]).Search for more papers by this author GEORGE J. CHRIST PhD, Corresponding Author GEORGE J. CHRIST PhD Professor Departments of Urology and Physiology & Biophysics, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New YorkDepartments of Urology and Physiology & Biophysics, Ben Marden Distinguished Scholar in Urology, Director, Institute for Smooth Muscle Biology, Room 744, Forchheimer Bldg, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461 (e-mail: [email protected]).Search for more papers by this author First published: 02 January 2013 https://doi.org/10.1002/j.1939-4640.2002.tb02291.xCitations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Aguilar-Bryan L., Clement JP IV, Gonzalez G., Kunjilwar K., Babenko A., Bryan J. Toward understanding the assembly and structure of KATP channels. Physiol Rev. 1998; 78: 227–245. Ashcroft FM. Ion Channels and Disease. New York, NY: Academic Press; 2000. Babenko AP, Aguilar-Bryan L., Bryan J. A view of sur/KIR6.X, KATP channels. Annu Rev Physiol. 1998; 60: 667–687. Brink PR, Valiunas V., Christ GJ. Homotypic, heterotypic and heteromeric gap junction channels. In: C. Perachia, ed. Current Topics in Membranes. Vol 49. New York, NY: Academic Press; 2000: 43–60. Chitaley K., Wingard CJ, Webb Clinton R., Branam H., Stopper VS, Lewis RW, Mills TM. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med. 2001; 1: 119–122. Christ GJ. The penis as a vascular organ: the importance of corporal smooth muscle tone in the control of erection. Urol Clin North Am. 1995; 22: 727–745. Christ GJ. Erection. In: E. Knobil, JD Neill, eds. The Encyclopedia of Reproduction. Vol 2. San Diego, Calif: Academic Press; 1998a: 38–49. Christ GJ. A new frontier: gene therapy for erectile dysfunction. In: A. Morales, ed. Current Concepts in the Treatment of Erectile Dysfunction. Hampshire, United Kingdom: Martin Dunitz Publishers; 1998b: 209–230. Christ GJ. Gap junctions and ion channels: relevance to erectile dysfunction. Int J Impotence Res. 2000a: S15–S25. Christ GJ. Gene therapy: future strategies and therapies. Drugs Today. 2000b; 36: 175–184. Christ GJ. K+ channels and gap junctions in the modulation of corporal smooth muscle tone. Drug News Perspect. 2000c; 13: 28–36. Christ GJ, Moreno AP, Melman AP, Spray DC. Gap junction-mediated intercellular diffusion of Ca2+ in cultured human corporal smooth muscle cells. Am J Physiol. 1992; 263: C373–C383. Christ GJ, Rehman J., Day N., Salkoff L., Valcic M. Melman A., Geliebter J. Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function. Am J Physiol. 1998; 275: H600–H608. Christ GJ, Richards S., Winkler A. Integrative erectile biology: the role of signal transduction and cell-to-cell communication in coordinating corporal smooth muscle tone and penile erection. Int J Impotence Res. 1997; 9: 1–16. Christ GJ, Spray DC, Brink PR. Characterization of K currents in cultured human corporal smooth muscle cells. J Androl. 1993; 14: 319–328. Christ GJ, Wang H-Z, Venkateswarlu K., Zhao W., Day NS. Ion channels and gap junctions: their role in erectile physiology, dysfunction and future therapy. Mol Urol. 1999; 3: 61–74. Giangiacomo KM, Fremont V., Mullmann TJ, Hanner M., Cox RH, Garcia ML. Interaction of charybdotoxin S10A with single maxi-K channels: kinetics of blockade depend on the presence of the beta 1 subunit. Biochemistry. 2000; 39: 6115–6122. Inagaki N., Seino S. ATP-sensitive potassium channels: structures, functions, and pathophysiology. Jpn J Physiol. 1998; 48: 397–412. Jones EM, Gray-Keller M., Fettiplace R. The role of Ca2+-activated K+ channel spliced variants in the tonotopic organization of the turtle cochlea. J Physiol. 1999; 518(pt 3): 653–665. Jones EM, Laus C., Fettiplace R. Identification of Ca(2+)-activated K+ channel splice variants and their distribution in the turtle cochlea. Proc R Soc Lond B Biol Sci. 1998; 265: 685–692. Knaus HG, Eberhart A., Koch RO, Munujos P., Schmalhofer WA, Warmke JW, Kaczorowski GJ, Garcia ML. Characterization of tissue-expressed alpha subunits of the high conductance Ca(2+)-activated K+ channel. J Biol Chem. 1995; 270: 22434–22439. Lawson K. Potassium channel activation: a potential therapeutic approach Pharmacol Ther. 1996; 70: 39–63. Lawson K. Potassium channel openers as potential therapeutic weapons in ion channel disease. Kidney Int. 2000; 57: 838–845. Lawson K., Dunne MJ. Peripheral channelopathies as targets for potassium channel openers. Expert Opin Investig Drugs. 2001; 10: 1345–1359. Lee SW, Wang H-Z, Christ GJ. Characterization of ATP-sensitive potassium channels in human corporal smooth muscle cells. Int J Impotence Res. 1999a; 11: 189–199. Lee SW, Wang H-Z, Zhao W., Ney P., Brink PR, Christ GJ. Prostaglandin E1 activates the large conductance KCa channel in human corporal smooth muscle. Int J Impotence Res. 1999b; 11: 179–188. Malysz J., Gibbons SJ, Miller SM, Gettman M., Nehra A., Szurszewski JH, Farrugia G. Potassium outward currents in freshly dissociated rabbit corpus cavernosum myocytes. J Urol. 2001; 166: 1167–1177. Melman A., Christ GJ. Integrative erectile biology: the effects of age and disease on gap junctions and ion channels and their potential value to the treatment of erectile dysfunction. Urol Clin North Am. 2001; 28: 217–231. Mills TM, Chitaley K., Lewis RW. Vasoconstrictors in erectile physiology. Int J Impotence Res. 2001; 5 (13 suppl): S29–S34. Pryor JL, Redmon B. New therapies and delivery mechanisms for treatment of erectile dysfunction. Int J Impotence Res. 2000; 12: S158–S162. Ramanan SV, Brink PR, Christ GJ. Neuronal innervation, intracellular signal transduction and intercellular coupling: a model for syncytial tissue responses in the steady state. J Theor Biol. 1998; 193: 69–84. Rees RW, Ralph DJ, Royle M., Moncada S., Cellek S. Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum. Br J Pharmacol. 2001; 133: 455–458. Rees RW, Ziessen T., Ralph DJ, Kell P., Moncada S., Cellek S. Human and rabbit cavernosal smooth muscle cells express Rho-kinase. Int J Impotence Res. 2002; 14: 1–7. Schenk G., Melman A., Christ GJ. Gene therapy: future therapy for erectile dysfunction. Curr Urol Rep. 2001; 2: 480–487. Seino S. ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies. Annu Rev Physiol. 1999; 61: 337–362. Spektor M., Rodriguez Ramon R., Rosenbaum S., Wang H-Z, Melman A., Christ GJ. K channels and human corporal smooth muscle cell tone: further evidence for the physiological relevance of the maxi-K channel subtype to the regulation of human corporal smooth muscle tone in vitro. J Urol. 2002; 167: 2628–2635. Toro L., Wallner M., Meera P., Tanaka Y. Maxi-K(Ca), a unique member of the voltage-gated K channel superfamily. News Physiol Sci. 1998; 13: 112–117. Venkateswarlu K., Christ GJ. Physiological roles for K+ channels and gap junctions in urogenital smooth muscle: implications for improved understanding of urogenital function, disease and therapy. Curr Drug Targets. 2001; 2: 1–20. Venkateswarlu K., Giraldi A., Zhao W., Wang H-Z, Melman A., Spektor M., Christ GJ. K channels and human corporal smooth muscle cell tone: diabetes and relaxation of human corpus cavernosum smooth muscle by KATP channel openers. J Urol. 2002; 168: 355–361. Wallner M., Meera P., Ottolia M., Kaczorowski GJ, Latorre R., Garcia ML, Stefani E., Toro L. Characterization of and modulation by a betasubunit of a human maxi KCa channel cloned from myometrium. Receptors Channels. 1995; 3: 185–199. Wang H-Z, Lee SW, Christ GJ. Comparative studies of the maxi-K (KCa) channel in freshly isolated myocytes of human and rat corpora. Int J Impotence Res. 2000; 12: 9–18. Xie J., McCobb DP. Control of alternative splicing of potassium channels by stress hormones. Science. 1998; 280: 443–446. Zhao W., Christ GJ. Endothelin-1 as a putative modulator of erectile dysfunction. II. Calcium mobilization in cultured human corporal smooth muscle cells. J Urol. 1995; 154: 1571–1579. Citing Literature Volume23, Issue5September‐October 2002Pages S10-S19 ReferencesRelatedInformation

Referência(s)
Altmetric
PlumX