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Platelet-derived growth factor induces c-fms and scavenger receptor genes in vascular smooth muscle cells.

1992; Elsevier BV; Volume: 267; Issue: 18 Linguagem: Inglês

10.1016/s0021-9258(18)42387-3

1083-351X

Tomohiro Inaba, Takanari Gotoda, Hitoshi Shimano, Masako Shimada, Kenji Harada, K Kozaki, Yuichiro Watanabe, Eitetsu Hoh, K Motoyoshi, Y Yazaki,

Cholesterol and Lipid Metabolism

Vascular smooth muscle cells proliferate and transform to foam cells in the process of atherosclerosis. In the present study, we demonstrated that platelet-derived growth factor (PDGF)-BB induced expression of proto-oncogene c-fms in vascular smooth muscle cells, which normally do not express c-fms, isolated from either human umbilical artery or rabbit aorta. No effect of the protein kinase C activator, phorbol ester, was demonstrated on mRNA expression of c-fms. In contrast, the scavenger receptor activity was induced by both PDGF-BB and phorbol ester. These results indicate that two characteristic genes of monocyte-macrophages were induced by PDGF-BB via the different pathways, and suggest that PDGF-BB plays an important role in initiating phenotypic conversion of smooth muscle cells to macrophage-like cells.