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The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes.

1980; Elsevier BV; Volume: 255; Issue: 4 Linguagem: Inglês

10.1016/s0021-9258(19)86092-1

1083-351X

Paul F. Pilch, Michael Czech,

Adipose Tissue and Metabolism

Insulins modified either at lysine Bzs with an acetyl group or at phenylalanine B1 with a phenylthiocarbamoyl group were both readily cross-linked to the receptor with roughly equal efficiency.It is concluded that the B1 terminal amino and Bzs lysine amino groups are both accessible for cross-linking of insulin to the receptor by disuccinimidyl suberate.