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Cutting Edge: Differential Chemokine Production by Myeloid and Plasmacytoid Dendritic Cells

2002; American Association of Immunologists; Volume: 169; Issue: 12 Linguagem: Inglês

10.4049/jimmunol.169.12.6673

1550-6606

Giuseppe Penna, Marisa Vulcano, Andrea Roncari, Fabio Facchetti, Silvano Sozzani, Luciano Adorini,

Chemokine receptors and signaling

Abstract To examine the different roles of myeloid dendritic cells (M-DCs) and plasmacytoid dendritic cells (P-DCs) in the induction and regulation of immune response, we have studied chemokine secretion by freshly isolated DC subsets in response to bacterial, viral, and T cell-derived stimuli. M-DCs selectively produced very high levels of the homeostatic chemokines CC chemokine ligand (CCL)17 and CCL22, while P-DCs produced very little if any. In contrast, the proinflammatory chemokine CCL3 was secreted mostly by P-DCs, whereas CCL4 and CXC chemokine ligand 8 were produced by both subsets. The selective production of CCL17 and CCL22 by M-DCs but not P-DCs was confirmed in vivo by immunohistology on human reactive lymph node sections. The high production of CCR4 ligands by M-DCs suggests their capacity to selectively recruit at sites of inflammation T cells with regulatory properties or with a Th2 phenotype, whereas P-DCs, by preferentially secreting CCR1/CCR5 ligands, would mostly recruit effector T cells and, in particular, Th1-type cells.