Mast Cells: Immunologically Specific Effectors and Potential Sources of Multiple Cytokines During IgE‐Dependent Responses
2007; Wiley; Linguagem: Inglês
10.1002/9780470513866.ch5
ISSN1935-4657
AutoresStephen J. Galli, Barry K. Wershil, John Gordon, Thomas R. Martin,
Tópico(s)Immune Cell Function and Interaction
ResumoMast Cells: Immunologically Specific Effectors and Potential Sources of Multiple Cytokines During IgE-Dependent Responses Stephen J. Galli, Stephen J. Galli Departments of Pathology, Beth Israel Hospital and Harvard Medical School, and the Charles A. Dana Research Institute, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215, USASearch for more papers by this authorBarry K. Wershil, Barry K. Wershil Departments of Pathology, Beth Israel Hospital and Harvard Medical School, and the Charles A. Dana Research Institute, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215, USA Combined Pediatric Gastroenterology and Nutrition Program, Harvard Medical School, Boston, MA 02115, USASearch for more papers by this authorJohn R. Gordon, John R. Gordon Departments of Pathology, Beth Israel Hospital and Harvard Medical School, and the Charles A. Dana Research Institute, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215, USASearch for more papers by this authorThomas R. Martin, Thomas R. Martin Departments of Pathology, Beth Israel Hospital and Harvard Medical School, and the Charles A. Dana Research Institute, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215, USA Department of Pediatrics, Children's Hospital, (Ina Sue Perlmutter Laboratory), Boston, MA 02115, USASearch for more papers by this author Stephen J. Galli, Stephen J. Galli Departments of Pathology, Beth Israel Hospital and Harvard Medical School, and the Charles A. Dana Research Institute, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215, USASearch for more papers by this authorBarry K. Wershil, Barry K. Wershil Departments of Pathology, Beth Israel Hospital and Harvard Medical School, and the Charles A. Dana Research Institute, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215, USA Combined Pediatric Gastroenterology and Nutrition Program, Harvard Medical School, Boston, MA 02115, USASearch for more papers by this authorJohn R. Gordon, John R. Gordon Departments of Pathology, Beth Israel Hospital and Harvard Medical School, and the Charles A. Dana Research Institute, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215, USASearch for more papers by this authorThomas R. Martin, Thomas R. Martin Departments of Pathology, Beth Israel Hospital and Harvard Medical School, and the Charles A. Dana Research Institute, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215, USA Department of Pediatrics, Children's Hospital, (Ina Sue Perlmutter Laboratory), Boston, MA 02115, USASearch for more papers by this author Book Editor(s):Derek J. Chadwick, Derek J. Chadwick OrganizerSearch for more papers by this authorDavid Evered, David Evered OrganizerSearch for more papers by this authorJulie Whelan, Julie WhelanSearch for more papers by this author First published: 28 September 2007 https://doi.org/10.1002/9780470513866.ch5Citations: 5Book Series:Novartis Foundation Symposia AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary Mast cells are critical effectors in many IgE-dependent responses, and the numbers and phenotype of certain mast cell populations can be influenced, through IL-3 and IL-4, by the same T cells that regulate IgE production. However, IgE can interact with cells other than mast cells, and different mast cell populations express significant variation in multiple important aspects of their phenotype, including mediator content and responses to cytokines and stimuli of activation. As a result it may be difficult to define the unique contributions of mast cells to IgE-dependent reactions. One approach for analysing the roles of various mast cell populations in individual biological responses is to attempt to elicit these reactions in mice in which the presence or absence of specific mast cell populations can be regulated experimentally. We have used genetically mast cell-deficient and mast cell-reconstituted mice to demonstrate that mast cells provide essential effector function in certain IgE-dependent responses involving the skin, stomach or lungs but are not necessary for the pulmonary alterations and death associated with active anaphylaxis. Similar approaches can be used to investigate the biological significance of the production, by mast cells stimulated with IgE and specific antigen, of cytokines similar or identical to IL-I, IL-3, IL-4, 1L-5, IL-6, TNF-αcachectin, IFN-γ, GM-CSF, JE, MIP-1β, MIP-IP and TCA3. 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