Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Antidiabetic and Antilipidemic Effects of Manilkara zapota

2014; Mary Ann Liebert, Inc.; Volume: 18; Issue: 3 Linguagem: Inglês

10.1089/jmf.2013.0170

1557-7600

Sandra Maria Barbalho, Patrícia Cincotto dos Santos Bueno, Débora Souza Delazari, Élen Landgraf Guiguer, Daniel Pereira Coqueiro, Adriano Cressoni Araújo, Maricelma da Silva Soares de Souza, Flávia Maria Vasques Farinazzi-Machado, Claudemir Gregório Mendes, Milton Groppo,

Cholesterol and Lipid Metabolism

Manilkara zapota is a tropical evergreen tree belonging to the Sapotaceae family; its parts are used in alternative medicine to treat coughs and colds and possess diuretic, antidiarrheal, antibiotic, antihyperglycemic, and hypocholesterolemic effects. There are no studies on metabolic profile after using the fruit, and this study aimed at evaluating the effects of the leaf and pulp of M. zapota fruit on the metabolic profile of Wistar rats. Male rats were treated for 50 days with M. zapota leaf juice or fruit juice, after which their biochemical and body composition profiles were analyzed (glycemia, triglycerides, high-density lipoprotein cholesterol (HDL-c), insulin, leptin, aspartate transaminase, alanine aminotransferase, Lee Index, and body mass index). Our results indicate significantly lower levels of glycemia, insulin, leptin, cholesterol, and triglycerides and augmented levels of HDL-c in animals treated with the leaves or fruit of this plant. The percentage of weight gain also declined in animals treated with M. zapota fruit pulp. The use of the M. zapota may be helpful in the prevention of obesity, diabetes, dyslipidemia, and their complications.