Aqueous Solubility in Discovery, Chemistry, and Assay Changes
2003; Wiley; Linguagem: Inglês
10.1002/3527601473.ch9
ISSN1865-0562
Autores Tópico(s)Analytical Chemistry and Chromatography
ResumoChapter 9 Aqueous Solubility in Discovery, Chemistry, and Assay Changes Dr. Chris Lipinski, Dr. Chris Lipinski christopher_a_lipinski@groton.pfizer.com Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USASearch for more papers by this author Dr. Chris Lipinski, Dr. Chris Lipinski christopher_a_lipinski@groton.pfizer.com Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USASearch for more papers by this author Book Editor(s):Dr. Han van de Waterbeemd, Dr. Han van de Waterbeemd P.zer Global Research and Development, Department of Drug Metabolism, IPC 351, Sandwich, Kent CT13 9NJ, UKSearch for more papers by this authorProf. Dr. Hans Lennernäs, Prof. Dr. Hans Lennernäs Biopharmaceutics Group, Department of Pharmacy, Uppsala University, S-751 23 Uppsala, SwedenSearch for more papers by this authorProf. Dr. Per Artursson, Prof. Dr. Per Artursson Division of Pharmaceutics, Department of Pharmacy, Uppsala University, S-751 23 Uppsala, SwedenSearch for more papers by this author First published: 27 May 2003 https://doi.org/10.1002/3527601473.ch9Citations: 15Book Series:Methods and Principles in Medicinal Chemistry Series Editor(s): Prof. Dr. Raimund Mannhold, Prof. Dr. Raimund Mannhold Biomedical Research Center, Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstraße 1, 40225 Düsseldorf, GermanySearch for more papers by this authorProf. Dr. Hugo Kubinyi, Prof. Dr. Hugo Kubinyi BASF AG Ludwigshafen, c/o Donnersbergstraße 9, 67256 Weisenheim am Sand, GermanySearch for more papers by this authorProf. Dr. Gerd Folkers, Prof. Dr. Gerd Folkers Department of Applied Biosciences, ETH Zürich, Winterthurerstr. 190, 8057 Zürich, SwitzerlandSearch for more papers by this author AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary This chapter contains sections titled: Introduction Compound Synthesis Compound Physical Form Compound Distribution Compound Physical Form: Ostwald's Rule of Stages Polymorph Form and Aqueous Solubility Implications for in vitro Assays Implications for in vivo Assays Solubility, Potency and Permeability Inter-relationships Acceptable Aqueous Solubility for Oral Activity Traditional Definition Current Era Definition Solubility in Practice: Development versus Discovery Development Thermodynamic Solubility as a Benchmark Turbidimetric/Particle-based Solubility UV Detector-based Solubility Other Methods-based Solubility Solids not Characterized in Early Discovery Solids Solubilized in DMSO in Early Discovery Citing Literature Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability RelatedInformation
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