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BIBTEX RIS

Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model

2015; BioMed Central; Volume: 15; Issue: 1 Linguagem: Inglês

10.1186/s12906-015-0694-4

ISSN

1472-6882

Autores

Lívia G. Castilhos, João Felipe Peres Rezer, Jader B. Ruchel, Maria Luiza Thorstenberg, Jeandre Augusto dos Santos Jaques, Josiane Bizzi Schlemmer, Pedro H. Doleski, Mateus F. Rossato, Mariane A. da Silva, Emerson André Casalli, Ritiel Corrêa da Cruz, Juliano Ferreira, Margareth Linde Athayde, Jamile F. Gonçalves, Daniela Bitencourt Rosa Leal,

Tópico(s)

Alkaloids: synthesis and pharmacology

Resumo

Considering that adjuvant arthritis is an experimental model of arthritis widely used for preclinical testing of numerous anti-arthritic agents, which were taken by a large number of patients worldwide, it is of great interest to investigate the therapeutic action of compounds with anti-inflammatory properties, such as Uncaria tomentosa extract. Moreover, there are no studies demonstrating the effect of U. tomentosa on the metabolism of adenine nucleotides published so far. Thus, the purpose of the present study is to investigate the effects of U. tomentosa extract on E-NTPDase and E-ADA activities in lymphocytes of Complete Freund's Adjuvant (CFA) arthritis induced rats.

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