Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Association between Mild Renal Dysfunction and Insulin Resistance or Metabolic Syndrome in a Random Nondiabetic Population Sample

2007; Karger Publishers; Volume: 30; Issue: 2 Linguagem: Inglês

10.1159/000100487

1423-0143

Altan Onat, Gülay Hergenç, Hüseyin Uyarel, Hakan Özhan, Ali Metin Esen, Ahmet Karabulut, Sinan Albayrak, Günay Can, İbrahim Keleş,

Diabetes, Cardiovascular Risks, and Lipoproteins

<i>Aims:</i> The association of mild renal dysfunction (estimated glomerular filtration rate [eGFR] 60–89.9 ml/min/1.73 m²) with insulin resistance (IR) or metabolic syndrome (MS) needs be investigated in a population in which MS prevails. <i>Methods:</i> After excluding subjects with diabetes mellitus, 1,678 subjects from a representative cohort (median age 52 years) were studied cross-sectionally. eGFR was based on serum creatinine concentrations using the quadratic GFR equation and categorized by 90 and 60 ml/min/1.73 m² as limits. MS was identified using the modified criteria of the Adult Treatment Panel-III. <i>Results:</i> In men, whereas MS was not significantly associated with a reduced eGFR category when controlled for homeostatic model assessment (HOMA), HOMA adjusted for MS or for its components was significantly associated with the likelihood of a reduced eGFR. This likelihood was increased by 14% with a doubling of HOMA in men. Age was the dominant correlate of reduced eGFR in women, whereby an association with HOMA was not significant. <i>Conclusion:</i> Mildly impaired kidney function is common in nondiabetic adults among whom MS prevails, and in men it is mainly associated with IR but not with central obesity and MS-related dyslipidemia. The quadratic GFR equation enables an acceptable estimation of GFR in a general population.