Portal de Periódicos da CAPES

NK Cells Stimulate Proliferation of T and NK Cells through 2B4/CD48 Interactions

2004; American Association of Immunologists; Volume: 173; Issue: 1 Linguagem: Inglês

10.4049/jimmunol.173.1.174

1550-6606

Erika Assarsson, Taku Kambayashi, John D. Schatzle, Sven O. Cramer, Arne von Bonin, Peter E. Jensen, Hans‐Gustaf Ljunggren, Benedict J. Chambers,

Immunotherapy and Immune Responses

Abstract Few studies have addressed the consequences of physical interactions between NK and T cells, as well as physical interactions among NK cells themselves. We show in this study that NK cells can enhance T cell activation and proliferation in response to CD3 cross-linking and specific Ag through interactions between 2B4 (CD244) on NK cells and CD48 on T cells. Furthermore, 2B4/CD48 interactions between NK cells also enhanced proliferation of NK cells in response to IL-2. Overall, these results suggest that NK cells augment the proliferation of neighboring T and NK cells through direct cell-cell contact. These results provide new insights into NK cell-mediated control of innate and adaptive immunity and demonstrate that receptor/ligand-specific cross talk between lymphocytes may occur in settings other than T-B cell or T-T cell interactions.