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Biosynthesis of bufadienolides in toads

1972; Pergamon Press; Volume: 3; Issue: 1 Linguagem: Inglês

10.1016/0022-4731(72)90006-4

1878-2353

A. M. Porto, Francisco E. Baralle, Eduardo G. Gros,

Steroid Chemistry and Biochemistry

The biosynthesis of bufadienolides in Bufo paracnemis toads has been studied in different seasons of the year using [2-14C]mevalonic acid, [20-14C]pregnenolone, and [20-14C]cholesterol as precursors. The results showed that the doubly unsaturated δ-lactone ring of the bufadieno-lides is directly derived from the cholesterol side chain without the compound's prior conversion into pregnenolone. The probable sequence in which the different bufadienolides are formed is discussed.