Synthesis of oxapenam derivatives.
1978; Pharmaceutical Society of Japan; Volume: 26; Issue: 2 Linguagem: Inglês
10.1248/cpb.26.448
ISSN1347-5223
AutoresS. OIDA, Akira Yoshida, Eiji Ohki,
Tópico(s)Synthesis of β-Lactam Compounds
ResumoPhotolysis of N-diazoacetyloxazolidine compounds, 7c and 8c, afforded oxapenams, 9 and 10, respectively. The physical data of 9 and 10 along with their behavior on thinlayer chromatograms were consistent with that of the samples derived from clavulanic acid (1), a β-lactamase inhibitor, confirming their structures. Further, a methylene oxapenam 18 was obtained from an oxapenam 17 having a phenylseleno group by selenoxide elimination reaction.
Referência(s)