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Trypanocidal activity of Piper arboreum and Piper tuberculatum (Piperaceae)

2009; Springer Science+Business Media; Volume: 19; Issue: 1b Linguagem: Inglês

10.1590/s0102-695x2009000200003

1981-528X

Luís Octávio Regasini, Fernando Cotinguiba, Gabriela Duó Passerini, Vanderlan da Silva Bolzani, Regina Maria Barretto Cicarelli, Massuo J. Kato, Maysa Furlan,

Traditional and Medicinal Uses of Annonaceae

In the scope of our ongoing research on bioactive agents from Brazilian flora, twenty-four extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for trypanocidal activity by using MTT colorimetric assay. The strongest activity was found in hexane fractions from the leaves of P. arboreum (IC50= 13.3 µg/ mL) and P. tuberculatum (IC50 = 17.2 µg/mL). Hexane fractions of the fruits of P. tuberculatum and P. arboreum showed potent toxic effects on epimastigote forms of Trypanosoma cruzi, with values of IC50 (µg/mL) of 32.2 and 31.3, respectively. Additionally, the phytochemical study of the hexane fraction of P. arboreum leaves furnished two pyrrolidine amides, piperyline (1) and 4,5-dihydropiperyline (2), which could be responsible, at least in part for the observed antiprotozoal activity.