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Rapidly Progressive Alzheimer's Disease: A Multicenter Update

2012; IOS Press; Volume: 30; Issue: 4 Linguagem: Inglês

10.3233/jad-2012-120007

1875-8908

Christian Schmidt, Stéphane Haı̈k, Katsuya Satoh, Alberto Rábano, Pablo Martínez‐Martín, Sigrun Roeber, Jean‐Philippe Brandel, Miguel Calero, Jesús de Pedro‐Cuesta, Jean Laplanche, J J Hauw, Hans Kretzschmar, Inga Zerr,

Neurological diseases and metabolism

The objective was to characterize a rapidly progressive subtype of Alzheimer's disease (rpAD). Multicenter (France, Germany, Japan, Spain) retrospective analyses of neuropathologically confirmed rpAD cases initially classified as prion disease due to their clinical phenotype were performed. Genetic properties, cerebrospinal fluid biomarkers, neuropathology, and clinical features were examined. Eighty-nine patients were included (median survival 10 months). APOE and PRNP codon 129 genotype distribution paralleled a healthy control group. APOE ε4 homozygosity was absent. Cerebrospinal fluid biomarkers were abnormal, but within a range as expected for classic AD, except for proteins 14-3-3, which were detectable in 42%. Thus, evidence of the existence of rpAD is accumulating. The APOE profile is intriguing, suggesting that this very rapid disease form might represent a distinct subtype of Alzheimer's disease.