Stimulation of 25-hydroxyvitamin D3-1alpha-hydroxylase by phosphate depletion.
1976; Elsevier BV; Volume: 251; Issue: 10 Linguagem: Inglês
10.1016/s0021-9258(17)33513-5
ISSN1083-351X
AutoresL.A. Baxter, Hector F. DeLuca,
Tópico(s)Vitamin D Research Studies
ResumoThe ability of low phosphorus diets to stimulate the activity of the 25-hydroxyvitamin D3-1alpha-hydroxylase was tested in the chick. Feeding low phosphorus diets for 2 weeks resulted in a marked increase in enzyme activity relative to chicks fed a normal phosphorus diet. Stimulation of the 25-hydroxyvitamin D3-1alpha-hydroxylase activity by low phosphorus diets, however, was not as great as that observed with a low calcium diet. The low phosphorus and low calcium diets probably results from increased 1,25-dihydroxyvitamin D3 synthesis, whereas the stimulation by phosphate deprivation is only partly the result of increased 1,25-dihydroxyvitamin D3 production.
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