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Site of reovirus replication in liver is determined by the type of hepatocellular insult

1990; American Society for Microbiology; Volume: 64; Issue: 9 Linguagem: Inglês

10.1128/jvi.64.9.4593-4597.1990

1098-5514

D H Rubin, Alexander H. Morrison, C.L. Witzleben, C J Guico, David A. Piccoli,

Escherichia coli research studies

Reovirus type 1 strain Lang is restricted from replicating in adult murine livers. In noninjured livers, approximately 1% of hepatocytes express reovirus antigen during infection. However, hepatocytes can be induced to express reovirus antigen if challenged with either toxins or trauma. We used selective hepatotoxins or surgical trauma to demonstrate that reovirus antigen localization in liver is determined by the site of hepatocellular insult and the timing of the virus inoculum.