Produção Nacional
Revisado por pares
The Effect of Clonazepam Mouthwash on the Symptomatology of Burning Mouth Syndrome: An Open Pilot Study: Table 1
2014; Oxford University Press; Volume: 15; Issue: 12 Linguagem: Inglês
10.1111/pme.12552
ISSN1526-4637
AutoresLuciano Alberto de Castro, Rejane Faria Ribeiro‐Rotta,
Tópico(s)Autoimmune Neurological Disorders and Treatments
ResumoDear Editor, Burning mouth syndrome (BMS) is a chronic idiopathic disorder characterized by burning sensation or dysesthesia in the tongue and other oral sites without clinical and laboratory findings, often accompanied by dry mouth, tingling, or dysgeusia. There is no standard recognized treatment. Considering the peripheral nervous alterations identified in BMS patients, some clinical trials have demonstrated the efficacy of topical clonazepam on BMS symptoms [1,2]. This study aimed to investigate the effect of clonazepam mouthwash on BMS symptomatology. The efficacy of topical clonazepam has been demonstrated in previous studies [1,2] where the drug was administrated as a mouth dissolving tablet. In addition, recent findings from an experimental animal study [3] demonstrated the presence of GABA A receptors in the tongue nerve fibers of rats. As benzodiazepines bind to GABA A receptors, these findings support the …
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