The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein.
1991; Springer Nature; Volume: 10; Issue: 10 Linguagem: Inglês
10.1002/j.1460-2075.1991.tb07840.x
ISSN1460-2075
AutoresMing Y. Lu, Zhaolong Gong, Weifeng Shen, Anthony D. Ho,
Tópico(s)CAR-T cell therapy research
ResumoResearch Article1 October 1991free access The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein. M. Lu M. Lu Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada. Search for more papers by this author Z.Y. Gong Z.Y. Gong Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada. Search for more papers by this author W.F. Shen W.F. Shen Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada. Search for more papers by this author A.D. Ho A.D. Ho Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada. Search for more papers by this author M. Lu M. Lu Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada. Search for more papers by this author Z.Y. Gong Z.Y. Gong Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada. Search for more papers by this author W.F. Shen W.F. Shen Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada. Search for more papers by this author A.D. Ho A.D. Ho Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada. Search for more papers by this author Author Information M. Lu1, Z.Y. Gong1, W.F. Shen1 and A.D. Ho1 1Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada. The EMBO Journal (1991)10:2905-2910https://doi.org/10.1002/j.1460-2075.1991.tb07840.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The t(10;14)(q24;q11) chromosomal translocation found in malignant cells of 5–10% of patients with T-cell acute lymphoblastic leukemia (T-ALL) involves the T-cell receptor delta chain gene on chromosome 14 and a breakpoint cluster region on chromosome 10. The candidate proto-oncogene tcl-3, thought to be involved in the pathogenesis of t(10;14) T-ALL, was cloned and found to be elevated in expression in leukemic cells harboring the t(10;14) translocation. Sequence analysis revealed that tcl-3 is a new homeobox-containing gene. Comparison of the tcl-3 cDNA and its 5′ genomic sequences with DNA sequences from the t(10;14) translocation breakpoints showed that this gene is structurally altered in four patients with t(10;14)(q24;q11) T-ALL. These findings suggest that homeobox-containing genes that normally act as transcription factors may contribute to T-cell leukemogenesis when abnormally expressed. Previous ArticleNext Article Volume 10Issue 101 October 1991In this issue RelatedDetailsLoading ...
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