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Control of Regulatory T Cell Migration, Function, and Homeostasis

2015; American Association of Immunologists; Volume: 195; Issue: 6 Linguagem: Inglês

10.4049/jimmunol.1500801

1550-6606

Daniel Campbell,

Immunotherapy and Immune Responses

Abstract Foxp3+ regulatory T cells (Tregs) are essential for preventing autoimmunity and uncontrolled inflammation, and they modulate immune responses during infection and the development of cancer. Accomplishing these tasks requires the widespread distribution of Tregs in both lymphoid and nonlymphoid tissues, and the selective recruitment of Tregs to different tissue sites has emerged as a key checkpoint that controls tissue inflammation in autoimmunity, infection, and cancer development, as well as in the context of allograft acceptance or rejection. Additionally, Tregs are functionally diverse, and it has become clear that some of this diversity segregates with Treg localization to particular tissue sites. In this article, I review the progress in understanding the mechanisms of Treg trafficking and discuss factors controlling their homeostatic maintenance and function in distinct tissue sites.