Biosynthetic Precursors of Vitamin K as Growth Promoters for Bacteroides melaninogenicus
1973; American Society for Microbiology; Volume: 116; Issue: 2 Linguagem: Inglês
10.1128/jb.116.2.965-971.1973
ISSN1098-5530
AutoresD. J. ROBINS, R B Yee, Ronald Bentley,
Tópico(s)Steroid Chemistry and Biochemistry
ResumoThe growth of a vitamin K-requiring strain of Bacteroides melaninogenicus was promoted by some postulated and proven biosynthetic precursors of bacterial menaquinones, 1,4-dihydroxy-2-naphthoic acid, shikimic acid, chorismic acid, and 4(2′-carboxyphenyl)-4-oxobutyric acid. Growth of the organism with [ 2 ′, 4 - 14 C 2 ]-4(2′-carboxy phenyl)-4-oxobutyric acid as the vitamin K replacement gave rise to a mixture of radioactive menaquinone-9 and menaquinone-10; the dilution factor for this incorporation was 1.8.
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