Portal de Periódicos da CAPES

Secondary Health Conditions Among Males With Duchenne Or Becker Muscular Dystrophy (DBMD) (S36.003)

2014; Lippincott Williams & Wilkins; Volume: 82; Issue: 10_supplement Linguagem: Inglês

10.1212/wnl.82.10_supplement.s36.003

1526-632X

Rebecca A. Napoliello, Natalie Street, Kristin Caspers, Emma Ciafaloni, Christopher Cunniff, Jennifer A. Donnelly, Deborah Fox, Kathy James, Joyce Oleszek, Christina Westfield,

Muscle Physiology and Disorders

Objective: To describe the frequency of secondary health conditions among males with Duchenne or Becker muscular dystrophy (DBMD). Background: The full spectrum of secondary health conditions in males with DBMD is unknown. A few studies suggest a higher than expected prevalence of a sub-set of conditions such as autism spectrum disorder, obsessive-compulsive disorder, constipation, and gastroesophageal reflux. Design/Methods: Caregivers of males with DBMD were identified through MD STARnet, a population-based surveillance system for DBMD in five states. Participants (n=209) were asked whether their child was ever diagnosed with any of twenty-nine conditions. Responses were categorized by affected male’s age, ambulatory status, and steroid-use. The responses were compared to those of the National Survey of Children’s Health (NSCH) when the questions were equivalent. Chi-square or Fisher’s exact test was used to analyze associations between categorical variables. The differences in means of continuous variables were evaluated with T-tests. Results: Males with DBMD aged >17 years were more likely to have depression (p<0.001), gastroesophageal reflux/heartburn (p= 0.029), and kidney stones (p<0.001) than males aged ≤17 years. Depression (p= 0.001), anxiety (p= 0.006), ADD/ADHD (0.022), gastroesophageal reflux/heartburn (p= 0.006), kidney stones (p= 0.007), trouble urinating (p= 0.010), and high blood pressure (p= 0.021) were more common among non-ambulatory males than ambulatory males. Cataracts were more common in long-term steroid users (蠅6months) than short-term (<6 months) or non-users (p<0.001). In comparison to NSCH participants, MD STARnet males had a higher percentage of behavioral and/or conduct problems, developmental delay, and intellectual disability (p 17 years and those who are non-ambulatory. Identification of these secondary conditions can ultimately improve clinical care and direct future research in this population. Disclosure: Dr. Napoliello has nothing to disclose. Dr. Street has nothing to disclose. Dr. Caspers has nothing to disclose. Dr. Ciafaloni has nothing to disclose. Dr. Cunniff has received research support from Genzyme Corp. Dr. Donnelly has nothing to disclose. Dr. Fox has nothing to disclose. Dr. James has nothing to disclose. Dr. Oleszek has nothing to disclose. Dr. Westfield has nothing to disclose.