Possible Role of Histamine in Rheumatoid Arthritis.
1981; Wiley; Volume: 36; Issue: 6 Linguagem: Inglês
10.1111/j.1398-9995.1981.tb01852.x
ISSN1398-9995
AutoresH. Permin, Per Stahl Skov, S. Norn, A. Geisler, R. Klysner, Vibeke Andersen, Allan Wiik, R. Manthorpe, Henning B. Nielsen, Jørgen Holm Petersen,
Tópico(s)Urticaria and Related Conditions
ResumoBasophilocytes from patients with rheumatoid arthritis (RA) responded to leukocyte nuclei from normal persons with histamine release; a similar histamine release induced by the nuclear components RNA and DNA has been demonstrated previously. A role of histamine in RA is also supported by the findings of clinical improvement during treatment with H 1 and H 2 antihistamines in six of 12 patients with RA in active phase, whereas four showed definite deterioration.
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