The Pathways of Thiamine Biosynthesis
1968; Elsevier BV; Volume: 243; Issue: 15 Linguagem: Inglês
10.1016/s0021-9258(18)93270-9
ISSN1083-351X
Autores Tópico(s)Alcoholism and Thiamine Deficiency
ResumoCertain thiamine-requiring auxotrophs of Neurospora crassa synthesize compounds related to the pyrimidine moiety of thiamine. The accumulation of these compounds was inhibited by thiamine and oxythiamine and stimulated by Zn++, Fe+++, and the purine analogues, 4-aminopyrazolo-pyrimidine and 2,6-diaminopurine. Bioautography revealed the presence in this medium of four compounds capable of serving as precursors of the pyrimidine moiety for the test organism, Enterobacter aerogenes strain PD1, and of several other compounds capable of serving as precursors of the thiazole moiety for an Escherichia coli thiazoleless strain.
Referência(s)