The inactivation of bradykinin in the pulmonary circulation of isolated lungs
1972; Wiley; Volume: 45; Issue: 2 Linguagem: Inglês
10.1111/j.1476-5381.1972.tb08084.x
ISSN1476-5381
Autores Tópico(s)Vitamin K Research Studies
Resumo1. The isolated lungs of guinea-pigs, rats and dogs, perfused with Krebs bicarbonate solution via the pulmonary artery, inactivated 95, 98 and 99% respectively of the bradykinin infused through them.2. This inactivation process was not inhibited by 2-mercaptoethanol (1 mM) or EDTA (500 muM).3. The inactivation was inhibited by 2:3-dimercaptopropanol (100 muM), N-ethylmaleimide (100 muM), and several of the bradykinin potentiating peptides from Bothrops jararaca, in both natural and synthetic forms.4. The effect of these compounds, 2-mercaptoethanol, EDTA, 2:3-dimercaptopropanol, N-ethylmaleimide and Bothrops peptides on the pulmonary bradykininase activity is the same as their effect on pulmonary angiotensin I converting enzyme.
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