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CordyMax™ Cs-4 Improves Glucose Metabolism and Increases Insulin Sensitivity in Normal Rats

2002; Mary Ann Liebert, Inc.; Volume: 8; Issue: 3 Linguagem: Inglês

10.1089/10755530260127998

1557-7708

Chunsheng Zhao, Weiti Yin, Jingyan Wang, Yan Zhang, Hong Yu, Raymond Cooper, Carsten Smidt, Jia-Shi Zhu,

Medicinal Plants and Bioactive Compounds

Objective: To evaluate effects of CordyMax™ Cs-4, a mycelial fermentation product of Cordyceps sinensis, on improving glucose metabolism and insulin sensitivity. Design: An in vivo pharmacology study. Subjects and Study Interventions: Adult Wistar rats, male and female, were given CordyMax 250 or 500 mg/kg per day or placebo for 17 days by gavage. Outcome Measurements: Fasting blood glucose, fasting plasma insulin, glucose-insulin index, and oral glucose tolerance. Results: Rats fed Cs-4 at either 250 or 500 mg/kg showed significantly reduced fasting blood glucose after the 17-day treatment, by 27% and 24% from baselines respectively (both p < 0.001). Examination of fasting plasma insulin demonstrated a 37% decrease in the high dose treatment groups (p = 0.012). Glucose-insulin index, an index of insulin sensitivity, increased by 10% and 17% in both 250 and 500 mg/kg groups (p = 0.008 and p = 0.0001, respectively). Oral glucose tolerance tests showed significantly improved glucose tolerance at 0.5, 1.0, and 2.0 hours after oral administration of a bolus of glucose (the area under the glucose curve: p = 0.05-0.006), but no change at 5 hours. Conclusion: CordyMax Cs-4 is effective in lowering basal blood glucose and plasma insulin, improving glucose metabolism by enhancing insulin sensitivity, and improving oral glucose tolerance.