Cellular change in human disease
1973; Elsevier BV; Volume: 4; Issue: 1 Linguagem: Inglês
10.1016/s0046-8177(73)80050-4
ISSN1532-8392
AutoresBenjamin F. Trump, Jon M. Valigorsky, Jane H. Dees, Wolfgang J. Mergner, Kook M. Kim, Raymond T. Jones, R. E. Pendergrass, Joel Garbus, R. Adams Cowley,
Tópico(s)Carcinogens and Genotoxicity Assessment
ResumoThe concept of evaluation of cellular alterations as a method for studying the pathogenesis and the manifestations of human disease is presented. Such study is based on evaluation by chemical and morphologic methods performed with human tissues obtained at immediate autopsy and is discussed in the context of cellular reaction to injury. The techniques discussed are readily available and comparable in resources required and difficulty of execution to many other specialized laboratory procedures presently in use. Now is an appropriate time to apply established cell biological principles to the study of human disease.
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