[46] Inflammatory responses to amyloid fibrils
1999; Academic Press; Linguagem: Inglês
10.1016/s0076-6879(99)09048-5
ISSN1557-7988
AutoresStephen L. Yates, June Kocsis‐Angle, Paula Embury, Kurt R. Brunden,
Tópico(s)Advanced Glycation End Products research
ResumoOur laboratory has routinely used the methodologies described here to characterize the effects of fibrillar A beta and amylin on cytokine synthesis and secretion by LPS-differentiated THP-1 cells. Because LPS-treated THP-1 cells resemble macrophage and microglia, this assay system represents an in vitro model of the potential interactions between A beta-containing senile plaques and microglia in the AD brain. As such, these methodologies should prove useful in the identification of compounds that inhibit this A beta-induced inflammatory response.
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