Synthetic studies on indoles and related compounds. XXV. The Friedel-Crafts acylation of ethyl 1H-indole-2-carboxylate. (2).
1990; Pharmaceutical Society of Japan; Volume: 38; Issue: 12 Linguagem: Inglês
10.1248/cpb.38.3261
ISSN1347-5223
AutoresMasanobu Tani, Tsuyoshi Aoki, Sadao ITO, Shigenobu Matsumoto, Mami HIDESHIMA, Kaoru FUKUSHIMA, Ryoichi NOZAWA, Takako MAEDA, M. TASHIRO, Yuusaku Yokoyama, Yasuoki Murakami,
Tópico(s)Synthesis and Biological Evaluation
ResumoThe Friedel-Crafts acylation of ethyl 1H-indole-2-carboxylate (1) with various acylating reagents having a functional group or hetero atom and the acylation of some derivatives (6, 7, 8, and 9) of ethyl 1H-indole-2-carboxylate (1) with simple acylating reagents are described. Acylation occurred at the C3-position or on the benzene moiety (mainly at the C5-position) of the indole nucleus. The regioselectivity of the above acylation of indoles (1, 6, 7, 8, and 9) is discussed.
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